FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to field of biotechnology, namely to obtaining versions of plasminogen and plasmin, containing one or several point mutations in catalytic domain, which reduce or prevent autocatalytic loss of plasmin protease activity, and can be used in medicine.
EFFECT: invention makes it possible to obtain autoproteolytically stable plasmin.
51 cl, 10 dwg, 3 tbl, 5 ex
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