FIELD: chemistry.
SUBSTANCE: invention relates to spiro derivatives of parthenin of formula 
, where R/R' is selected from a group consisting of phenyl or a substituted phenyl such as 4-ClC6H4, 2-NO2C6H4; 2,4-(MeO)2C6H3, 4-MeC6H4, and formula 
, where R is 4-MeOC6H4, 2-NO2C6H4, 3-NO2C6H4, 3-MeC6H4, 3-MeCO2C6H4. The invention also relates to methods of producing said spiro derivatives and a pharmaceutical composition based on said derivatives.
EFFECT: compounds of formula 1b and 1d have anticancer activity.
14 cl, 6 dwg, 6 tbl
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