FIELD: biotechnologies.
SUBSTANCE: method for inhibition of RNA-polymerase ferment activity is proposed. Inhibition is performed by introduction to a transcriptional system of an inhibitor based on at least one compound containing organic macrocyclic complex with encapsulated ion of transition metal, which has been chosen from the group including 1,8-bis(2-fluorobora)-2,7,9,14,15,20-hexaoxa-3,6,10,13,16,19-hexaasa-4,5,11,12-tetraphenyl-17,18-diamino-bicyclo[6.6.6]eicosa-3,5,10,12,16,18-hexaen(2-) ferrum(2+); 1,8-bis(2-fluorobora)-2,7,9,14,15,20-hexaoxa-3,6,10,13,16,19-hexaasa-4,5,11,12-tetraphenyl-17,18-dimethyl-bicyclo[6.6.6]eicosa-3,5,10,12,16,18-hexaen(2-) cobalt(2+); 1,8-bis(2-phenylbora)-2,7,9,14,15,20-hexaoxa-3,6,10,13,16,19-hexaasa-4,5,11,12,17,18-hexa(methyl thio)-bicyclo[6.6.6]eicosa-3,5,10,12,16,18-hexaen(2-) ruthenium(2+); 1,8-bis(2-fluorobora)-2,7,9,14,15,20-hexaoxa-3,6,10,13,16,19-hexaasa-4,5,11,12-tetraphenyl-17,18-cyclohexanedimercaptylbicyclo[6.6.6]eicosea-3,5,10,12,16,18-hexaen(2-) ferrum(2+); 1,12-bis-(tert-butylbora)-2,11,13,22,23,32-hexaoxa-3,10,14,21,24,31-hexasapentacyclo[11,11.11.04.9015,20025.30]ditri-akonta-3,9,14,20,24,30-hexaen(2-) ferrum(2+).
EFFECT: method provides for inhibition of activity of RNA-polymerase at micromolar concentration of inhibitor and enlarges the range of inhibitors of RNA-polymerase.
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