FIELD: medicine.
SUBSTANCE: there are presented insect models able to reflect a blood-brain barrier (BBB) permeability in a mammal, particularly human. The invention concerns a method for assessing the BBB chemical transport, as well as using insects in screening the chemical substances having a biological effect on the brain or central nervous system and/or having an effect on a disease or disorder involving the brain or central nervous system. The method involves: introducing the chemical into the insect with BBB; keeping the insects; preparing the insect brain and measuring the brain chemical concentration.
EFFECT: method improvement.
10 cl, 2 tbl, 12 ex
| Title | Year | Author | Number |
|---|---|---|---|
| POLYPEPTIDE CAPABLE OF OVERCOMING HEMATOENCEPHALIC BARRIER, AND CONJUGATE THEREOF | 2005 |
|
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| BLOOD BRAIN BARRIER SHUTTLE | 2013 |
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| SHUTTLE FOR BLOOD-BRAIN BARRIER | 2013 |
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| METHOD OF INCREASING BLOOD-BRAIN BARRIER PERMEABILITY | 2009 |
|
RU2391107C1 |
| METHOD FOR DETECTION OF INTESTINAL, AND BLOOD-BRAIN BARRIER PERMEABILITY AND TESTING MATERIALS THERETO RELATED APPLICATION | 2012 |
|
RU2607479C2 |
| SHUTTLE FOR BLOOD-BRAIN BARRIER | 2019 |
|
RU2754794C2 |
| APTAMER PASSING THROUGH MOUSE BLOOD-BRAIN BARRIER OF MOUSE BRAIN | 2016 |
|
RU2711912C2 |
