METHOD FOR SIMULATING FULMINANT SEPSIS CAUSED BY MIXED INFECTION WITH UNDERLYING BURNING INJURY Russian patent published in 2014 - IPC G09B23/28 

FIELD: medicine.

SUBSTANCE: fulminant sepsis is simulated by inducing a mixed infection with underlying a burning injury. For this purpose, a thermal injury of the area of 12-23% of the body surface in anaesthetised rabbits is applied by immersing the back and sides into water at temperature 90° for 10 seconds. That is followed by the subcutaneous introduction of the non-culturable culture Staphylococcus aureus 1.0 ml in the concentration of 10⁵ microbial cells in 1 ml. Then 60 minutes later, the non-culturable culture Pseudomonas aeruginosa is subcutaneously introduced in the amount of 1.0 ml in the concentration of 10⁵ microbial cells in 1 ml.

EFFECT: method enables studying the effect of the non-culturable mixed infection on the development of an infectious process caused in a susceptible organism, and developing the new laboratory diagnostic techniques; methods for treatment and prevention of fulminant sepsis in the environment of non-culturable bacteria circulation.

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