METHOD FOR PREDICTION OF PATHOGENETIC PROCESS DEVELOPMENT FOR NON-CULTURED OR CULTURED TYPE IN EXPERIMENT Russian patent published in 2018 - IPC G09B23/28 

FIELD: medicine.

SUBSTANCE: P. aeruginosa and S. aureus cultures are isolated from patients with pyoinflammatory processes, and fractions of cultured and non-cultured bacteria are obtained from them. Then, associations of such bacteria are administered to rabbits subcutaneously in an amount of 10⁴-10⁵ microbial cells in 1 ml. On day 1-2 and 4-5 after this, alkaline phosphatase and ALT in the blood serum of animals are determined. When the alkaline phosphatase value on day 1-2 is 205.0-391.0 u/L, and on day 4-5 - 308.0-483.0 u/L and ALT value on day 1-2 is 53.0-63.0 u/L, and on day 4-5 - 57.0-69.0 u/L, non-cultured type infection process development is predicted. When the alkaline phosphatase value on day 4-5 day is 485.0-652.0 u/L and ALT is 36.5-38.0 u/L, cultured type infection process development is predicted.

EFFECT: method provides prediction of development of various types of infection while ensuring simplicity and cheapness of simulation, the results of which can be used in the study of pathogenesis of disease in humans when developing methods for diagnostics and treatment of such patients.

2 ex, 2 tbl