METHOD FOR PREDICTION OF CUMMULATIVE CARDIAC TOXICITY OF CHEMOTHERAPEUTIC PREPARATIONS Russian patent published in 2014 - IPC A61B6/02 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, oncology, cardiology and may be used for the prediction of a cumulative cardiac toxicity of anthracycline chemotherapeutic preparations. The intravenous administration of anthracycline 50 mg/m² is preceded and further followed 1 hour later by an examination of left ventricular ejection fraction with using planar ECG-gated equilibrium radionuclide ventriculography by standard technique. A decrease of the left ventricular ejection fraction in response to the first administration of the preparation 10% and more as compared to the reference, the cumulative cardiac toxicity is predicted.

EFFECT: method enables predicting the developing cumulative cardiac toxicity in the patient after one anthracycline chemotherapeutic course, having sensitivity 50% and specificity 92% that enables initiating the prevention of cardiologic complications promptly that develop in various time intervals of the tumour treatment.

2 ex, 6 dwg