FIELD: medicine.
SUBSTANCE: invention relates to medicine, namely cardiology, oncology and therapy of internal diseases, and can be used for personalized selection of patients with anthracycline-induced cardiomyopathy after polychemotherapy of breast cancer for effective treatment with carvedilol. Prior to the start of cardiomyopathy treatment, the polymorphism Arg389Gly, rs1801253 of the ADRB1 gene is determined. In the case of the carrier genotype G/G of polymorphism Arg389Gly, rs1801253 of the ADRB1 gene, carvedilol is used daily in the morning and evening at a daily dose of 50 mg.
EFFECT: method provides an increase in the effectiveness of treatment, which makes it possible to increase the proportion of patients responding to pathogenetic therapy.
1 cl, 7 tbl, 2 ex
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