MIXED METAL COMPOUNDS APPLICABLE AS ANTACIDS Russian patent published in 2014 - IPC A61K9/16 A61K33/08 A61K33/10 A61K33/26 A61K33/30 A61P1/04 C01G49/00 C01F5/00 

Abstract RU 2510265 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to using mixed metal compounds for preparing a drug preparation for neutralisation of gastric acid or buffer action thereon, as well as for treatment of a condition or a disease related to high gastric levels of acid. The mixed metal compound is a compound of formula (I): MII1-aMIIIaObAn-c.zH2O (I), wherein MII and MIII mean a two-valence and three-valence metal respectively, An- means an n-valence anion, 0.2≤a≤0.4, 0.2≤b≤1.5, 2+a is equal to 2b+Σcn, Σcn<0.9a, and z is equal to 2 or less. According to the invention, the mixed metal compound is presented in the form of a granulated material, wherein a diametre of 50 wt % of the granules makes 106 to 1180 mcm with the material comprising 50 wt % of the mixed metal compound, 3 to 12 wt % of noncovalent water and no more than 47 wt % of an excipient on granulated material weight basis. The mixed metal compound in the form of the granulated material represents a compound of formula (I) or a compound of formula (III): MII1-xMIIIx(OH)2An-y·mH2O (III) ; wherein MII and MIII mean a two-valence and three-valence metal respectively, An- means an n-valence anion, x=Σyn, 0<x≤0.4, 0<y≤1, and 0≤m≤10.

EFFECT: invention provides the buffer action on gastric acid, causing no effect of rebound acid hypersecretion.

46 cl, 3 tbl, 1 dwg

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RU 2 510 265 C2

Authors

N'Juton Moris Sidni

Morrison Dzhejms Dejvid

Pennell Rut Dajan

Roudes Najdzhel Piter

Toft Aleksis Dzhon

Dates

2014-03-27Published

2008-07-24Filed