METHOD FOR MONITORING OF TREATMENT OF DISEASE INVOLVING FLUORESCENCE DIAGNOSTICS OF DISEASE, AND DEVICE FOR IMPLEMENTING IT Russian patent published in 2014 - IPC G01N21/64 

FIELD: medicine.

SUBSTANCE: group of inventions refers to laboratory diagnostics and may be used for diagnosis and monitoring of the treatment of various diseases. The method for monitoring of the treatment of the disease involves a fluorescence centre excitement of a biological fluid sample by the exposure to an emission of at least two wavelengths, and recording at least two spectra of the emission generated by the sample, respectively. The presence, degree and nature of the disease are identified by determining the spectral characteristics of the emission generated by the sample as compared to the respective reference (health) spectra and typical spectra of various diseases with the spectra compared within the range involving a laser emission dispersion line. The group of inventions also refers to a device for implementing the above method involving the lasers with various working wavelengths, fibre optic lines collected from the side of the sample into a bundle with a common tip, a spectrometer, a control unit and a computer to process the fluorescence spectra. The spectrometer comprises a collimator with removable optical light filter, a diffraction grating and a charge-coupled device matrix coupled with a signal pre-processor. The control unit regulates laser switching off/on and placing into a collimator of the optical light filter related to the switched-on laser.

EFFECT: group of inventions enables higher rate and accuracy of obtaining the analysis results.

7 cl, 1 dwg, 1 ex