FIELD: chemistry.
SUBSTANCE: invention relates to field of obtaining derivatives of ethyl 1,2,4-oxadiazole-5-carboxylates of general formula VII from respective amidoximes of general formula VI by interaction with diethyl ether of oxalic acid: 
Method includes mixing amidoxime of general formula VI with 3-fold excess of diethyl ether of oxalic acid with the following exposure at temperature 120°C for 3-4 hours. Separation of target ethyl 1,2,4-oxadiazole-5-carboxylate VII consists in cooling reaction mass to room temperature, filtering formed suspension and washing with dichloromethane.
EFFECT: method of obtaining derivatives of ethyl 1,2,4-oxadiazole-5-carboxylates with increased output of product without application of sodium ethoxide is elaborated Obtained derivatives of ethyl 1,2,4-oxadiazole-5-carboxylates can be applied in chemical industry as antibacterial medications or half-products in synthesis of antithrombotic, antiplatelet and antiparasitic medications.
1 tbl, 4 ex
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