DERIVATIVE, CONTAINING CONDENSED RING STRUCTURE, AND ITS APPLICATION IN MEDICINE Russian patent published in 2014 - IPC C07D213/79 C07D231/14 C07D215/52 C07D277/56 C07D271/06 C07D285/08 C07D275/03 C07D263/34 C07C255/57 A61K31/44 A61K31/415 A61K31/47 A61K31/426 A61K31/4245 A61K31/433 A61K31/425 A61K31/421 A61K31/192 A61P3/00 A61P13/04 A61P13/12 A61P19/00 A61P19/06 

Abstract RU 2512547 C2

FIELD: chemistry.

SUBSTANCE: claimed invention relates to compounds, represented by formula (I) , where X1 and X2 independently represent CH or N; ring U represents benzene ring, pyrazole ring, 1,2,4-oxadiazole ring, 1,2,4-thiadiazole ring, isothiazole ring, oxazole ring, pyridine ring, thiazole ring or thiophene ring, m represents integer number, which has values from 0 to 1; n represents integer number, which has values from 0 to 3; R1 represents hydroxygroup or C1-6 alkyl; R2 represents any of (1)-(3): (1) halogen atom; (2) hydroxygroup; (3) C1-6 alkyl or C1-6 alkoxy, each of which can independently contain any group, selected from group of substituents α; group of substituents α includes fluorine atom and hydroxygroup, or its pharmaceutically acceptable salt. Invention also relates to pharmaceutical composition, possessing inhibiting activity with respect to xanthenes oxidase, including formula (I) compound or its pharmaceutically acceptable salt as active ingredient.

EFFECT: derivative, which contains condensed ring structure, intended as means for prevention and treatment of disease, associated with abnormal level of uric acid in serum.

15 cl, 11 tbl, 126 ex

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RU 2 512 547 C2

Authors

Simizu Kazuo

Iizuka Masato

Fudzikura Khideki

Takigava Jasusi

Khiratoti Masakhiro

Dates

2014-04-10Published

2009-10-14Filed