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(19)

RU

(11)

2 515 611

(13)

C2

(51)

IPC

C07C251/86(2006-01-01)

A61K31/15(2006-01-01)

A61K31/16(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2011106799/04, 2009-07-22

(24)

Start date

2009-07-22

(22)

Actual filing date

2009-07-22

(45)

Published

2014-05-20

(72)

Inventor

Tan VehjpinBrehdner Dzhejms EhlliotShrajber Stjuart L.

(73)

Holder

Prezident Ehnd Fellouz Of Garvard KolledzhDana-Farber Kehnser Instit'Jut, Ink.

DEACETYLASE INHIBITORS AND THEIR APPLICATION Russian patent published in 2014 - IPC C07C251/86 A61K31/15 A61K31/16 A61P35/00 

Abstract RU 2515611 C2

FIELD: chemistry.

SUBSTANCE: invention relates to formula (I) compounds, where n stands for integer number from 1 to 10 including; m stands for integer number from 0 to 5 including; k stands for integer number from 0 to 5 including; p stands for integer number from 0 to 4 including; R2 stands for C(O)NHOH; R3 stands for hydrogen atom; lower alkyl or -ORC, where RC represents lower alkyl; R4 stands for hydrogen atom; lower alkyl or -ORD, where RD represents lower alkyl; R4 stands for hydrogen atom. Invention also relates to their pharmaceutical composition, inhibiting activity of histone deacetylase, which contains said compounds, and to method of inhibiting deacetylase activity.

EFFECT: compounds of formula (I) as deacetylase inhibitors.

18 cl, 9 dwg, 7 tbl, 4 ex

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RU 2 515 611 C2

Authors

Tan Vehjpin

Brehdner Dzhejms Ehlliot

Shrajber Stjuart L.

Dates

2014-05-20—Published

2009-07-22—Filed

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