METHOD AND AGENT ACTIVATING IRF-3 FOR TREATING AND PREVENTING DISEASES CAUSED BY (+) RNA CONTAINING VIRUSES Russian patent published in 2014 - IPC A61K38/05 A61P31/14 A61P31/16 

FIELD: medicine.

SUBSTANCE: there are presented: a method for preventing or treating diseases caused by (+)RNA containing viruses of the genus Enterovirus or Flavivirus (the virus of the genus Enterovirus is specified in a group consisting of rhinoviruses and enterovirus type 71; the virus of the genus Flavivirus is specified in a group consisting of West Nile virus, dengue virus, tick-borne encephalitis virus, Saint Louis encephalitis virus, Murray Valley encephalitis virus and yellow fever virus) providing the use of an effective amount of glutaryl histamine or its pharmaceutically acceptable salt. There are also presented: a pharmaceutical composition for the above application and formulation, and a kit, the use of glutaryl histamine or its pharmaceutically acceptable salt for preparing the pharmaceutical composition for preventing or treating the diseases caused by (+)RNA containing viruses of the genus Enterovirus or Flavivirus. It has been shown that glutaryl histamine inhibited the dengue virus replication, provided the 40% death protection of the mice infected by tick-borne encephalitis virus (protective activity of ribavirin made 15%).

EFFECT: improved properties of the agent.

22 cl, 8 tbl