FIELD: chemistry.
SUBSTANCE: method includes processing 1-(4-nitrophenyl)ethylnitrate with nucleophilic reagent in solution. As nucleophilic reagent used are ankoxides of alkali metals in solution in absolute organic solvent. Solution of nucleophilic reagent is added to solution of 1-(4-nitrophenyl)ethylnitrate in organic solvent for 10-20 min, after addition reaction is carried out without application of cooling for 5 min. After that, reaction mass is neutralised with acetic acid to pH=7 and by product - alkali metal nitrite is isolated in pure form. Target product is isolated, regenerating solvent by its distillation. Residue is diluted with water, and 4-nitroacetophenone is separated, without operation of forced evaporation of obtained after its separation mother liquor.
EFFECT: method makes it possible to considerably reduce time of synthesis and obtain 4-nitroacetophenone with high output.
1 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF PRODUCING 4-NITROSTYRENE | 2010 |
|
RU2432351C1 |
| REESTERIFICATION CATALYST AND PREPARATION METHOD THEREOF | 2006 |
|
RU2414299C2 |
| METHOD OF PRODUCING 1-PHENYL PROPARGYL ALCOHOL | 2012 |
|
RU2515241C1 |
| METALLATION AND FUNCTIONALIZATION OF POLYMERS AND COPOLYMERS | 1996 |
|
RU2190629C2 |
| METHOD OF PRODUCING 4-AMINOSTYRENE | 2012 |
|
RU2485094C1 |
| METHOD OF PREPARING NITROPHENYLALKYL ALCOHOLS | 0 |
|
SU771085A1 |
| METHOD OF PREPARING EPOXIDE | 1995 |
|
RU2137769C1 |
| METHOD OF PRODUCING 1-AMINO-4-VINYL BENZENE | 2011 |
|
RU2472773C1 |
| METHOD OF SYNTHESIS OF 3,5-DINITRO-1,2,4-TRIAZOLE SALTS | 2000 |
|
RU2174120C1 |
| METHOD OF SYNTHESIS OF DERIVATIVES OF O-(2-HYDROXY-3-PIPERIDINO-1-PROPYL)-NICOTINIC ACID AMIDEOXIME AND THEIR SALTS (VARIANTS), O-(2-HYDROXY-3-PIPERIDINO-1-PROPYL)-NICOTINIC ACID AMIDEOXIME PURE CRYSTALLINE BASE | 1990 |
|
RU2074854C1 |
