1-ARYL-3-AMINOALKOXYPYRAZOL AS SIGMA LIGANDS INTENSIFYING ANALGESIC ACTION OF OPIOIDS AND RELIEVING ADDICTION THERETO Russian patent published in 2014 - IPC A61K31/4152 A61K31/4155 A61K31/485 A61K31/4468 A61K31/138 A61P25/04 A61P25/36 

FIELD: medicine, pharmaceutics.

SUBSTANCE: there are presented: a combination possessing analgesic action of at least one sigma ligand and at least one opioid or opiate compound specified in morphine and its structural derivatives, phentanyl and tramadol for simultaneous, separate or sequential administration; the sigma ligand has the general formula ;

using it for preparing a therapeutic agent potentiating analgesic action of morphine or its structural derivatives, phentanyl and tramadol and/or relieving addiction thereto. What is also presented is using the combination of at least one sigma ligand and at least one opioid or opiate compound for preparing the therapeutic agent for potentiating analgesic action of opioids or opiates and for relieving addiction thereto; the opiate is specified in a group of: hydromorphone, oxymorphone, desomorphine, diacetylmorphine, nicomorphine, dipropanoylmorphine, benzylmorphine and ethylmorphine.

EFFECT: what is shown is the synergetic analgesic action of the morphine and compound 63 combination; the compound appeared to relieve the effects of positive stimulation caused by morphine with establishment of behaviour reflex.

16 cl, 10 dwg