STABILISED PHARMACEUTICAL SUBMICRON SUSPENSIONS AND METHODS FOR PREPARING THEM Russian patent published in 2014 - IPC A61K9/00 A61K9/10 A61K47/38 A61P27/02 

FIELD: medicine, pharmaceutics.

SUBSTANCE: group of inventions refers to a pharmaceutical submicron suspension and to a method for preparing the submicron suspension and is applicable for ophthalmic (local or intravitreal) and nasal application. The ophthalmic aqueous pharmaceutical submicron suspension contains a hydrophobic therapeutic agent prepared in the form of submicron particles with the hydrophobic therapeutic agent presenting nepafenac; where a low-molecular charged polymer contains one or more cellulose polymers which jointly or individually have a molecular weight of less than 200000 kilodalton, and wherein the low-molecular charged polymer has an average degree of polymerisation (DP) making approximately min. 100 and up to approximately 4000; and one or more additives. The low-molecular charged polymer inhibits submicron particle aggregation in the suspension; the submicron particles have an average hydrodynamic radius making less than 1 mcm, and the low-molecular charged polymer represents carboxymethyl cellulose.

EFFECT: using the group of inventions enables preparing the high-active therapeutic agent for ophthalmic application.

16 cl, 5 tbl, 1 ex