AQUEOUS PHARMACEUTICAL COMPOSITIONS, CONTAINING BORATE-POLYOL COMPLEXES Russian patent published in 2015 - IPC A61K9/00 A61K31/47 A61K31/69 A61K47/10 A61P27/02 

FIELD: medicine, pharmaceutics.

SUBSTANCE: group of inventions relates to field of medicine, namely to ophthalmology, and is intended for treating eye in mammals. Multi-dose ophthalmological composition includes therapeutically effective quantity of brimonidine. Formulation of composition also includes first polyol, selected from mannitol, sorbitol or their combination. Concentration of first polyol constitutes at least 0.15 wt/vol %, but less than 0.5 wt/vol % of the total composition formulation. Composition formulation includes second polyol, selected from propyleneglycol, glycerol or their combination. Concentration of second polyol constitutes at least 0.3 wt/vol %, but less than 1.2 wt/vol % of the total composition formulation. Composition includes borate, concentration of which constitutes at least 0.1 wt/vol % but less than approximately 0.5 wt/vol %; benzalkonium chloride, concentration of which constitutes more than 0.0007 wt/vol %, but less than 0.0035 wt/vol %; and water. Composition has ph lower than 7.0.

EFFECT: application of group of inventions makes it possible to provide excellent preservation efficiency and sufficient antimicrobial activity in order to correspond to requirements of USP preservation efficiency as well as to similar standards for preservatives (for instance, European pharmacopeia and JP).

22 cl, 11 tbl, 5 ex