OPHTHALMIC COMPOSITION WITH VISCOSITY ENHANCEMENT SYSTEM HAVING TWO DIFFERENT VISCOSITY ENHANCING AGENTS Russian patent published in 2016 - IPC A61K9/00 A61K47/10 A61K47/32 A61K47/34 A61K47/38 A61P27/02 

FIELD: medicine.

SUBSTANCE: group of inventions relates to medicine, specifically to ophthalmology, and is intended for local administration of ophthalmic multi-dose aqueous composition in eye of a mammal. Said composition contains a therapeutically effective amount of a therapeutic agent, to increase viscosity of system and water. System consists of a soluble viscosity enhancing agent with concentration from about 0.10 wt%/vol to about 2.5 wt%/vol and heat-sensitive viscosity enhancing agent with concentration from about 0.80 wt%/vol to not more than 10 wt%/vol. Soluble viscosity enhancing agent provides a composition with additional viscosity, which is equal to 5 cP to not more than 100 cP.

EFFECT: use of group of inventions provides higher permeability of therapeutic agent in an eye of a mammal, and reduces symptoms of dry eye.

12 cl, 2 tbl