METHOD FOR EARLY PREVENTION OF GESTATIONAL COMPLICATIONS Russian patent published in 2014 - IPC G01N33/53 G01N33/74 

FIELD: medicine.

SUBSTANCE: method involves detecting a threatening miscarriage and a carrier state of the polymorphism in the gene of folate metabolism, as well as a CD54⁺ lymphocyte ratio, lactoferrin and β-subunit of human chorionic gonadotropin (β-HCG) levels in venous blood of a pregnant woman from the onset of pregnancy to the end of the first trimester. That is followed by calculating a prognostic index (PI) by formula: PI=0.7199X₁+1.2552X₂-0.00653X₃-0.0009X₄+0.0722X₅+1.1277, wherein X₁ is the threatening miscarriage, yes/no (1/0); X₂ is the polymorphism in the gene of folate metabolism, yes/no (1/0); X₃ is the CD54⁺ lymphocyte ratio, %; X₄ is the lactoferrin level, ng/ml; X₅ is the concentration of the free β-subunit of human chorionic gonadotropin (β-HCG), ng/ml. If PI<0, the gestational complications are predicted, while PI>0 enables stating a low risk of pathological conditions accompanying pregnancy. A sensitivity of the presented method makes 81.2%, its specificity is 85.1%. The method effectiveness is 83.2%.

EFFECT: method is minimally invasive, enables identifying a risk group of the gestational complications early that makes it possible to implement preventive measures aiming at preventing the pathological course of the pregnancy.

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