METHOD OF PREDICTING RETARDATION OF INTRAUTERINE FOETUS DEVELOPMENT Russian patent published in 2014 - IPC G01N33/533 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to obstetrics and gynaecology, and can be used for the prediction of retardation of intrauterine foetus development. For this purpose a relative content of CD3⁺CD16⁺56⁺-lymphocytes, a level of C3-component of the complement and the soluble receptor of tumour necrosis factor (sTNF-R) are determined in a woman's venous blood at early terms of pregnancy. The prognostic index (PI) is calculated by formula: PI=-0.8911X₁-0.0321X₂-2.3669X₃+11.0779, where X₁ is the relative content of CD3⁺CD16⁺56⁺-lymphocytes, %; X₂ is the concentration of C3-component of the complement, mg/dl; X₃ is the concentration of sTNF-R, ng/ml. If PI<0 retardation of intrauterine foetus growth in the second half of pregnancy is predicted, and if PI>0, a conclusion about a low risk of development of the said pathologic condition is made.

EFFECT: method is low-invasive, makes it possible to identify a risk group by the formation of retardation of intrauterine foetus development from the early terms of gestation, which makes it possible to carry out preventive procedures aimed at the prevention of the said pathological condition.

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