FIELD: medicine.
SUBSTANCE: invention relates to molecular genetic diagnostics in oncology, and can be used for prediction of risk of prostate cancer. What is presented is a method for predicting the risk of developing prostate cancer. Deoxyribonucleic acid DNA is recovered from peripheral venous blood. Then SNP single-nucleotide polymorphisms are analyzed: rs4430796 of the HNF1B gene C>T, rs1859962 of the CASC17 gene A>C, rs1447295 of the CASC8 gene G>T, rs6983267 CCAT2 G>T. A genomic combination is determined by a combination of alleles of the listed genes. When detecting genomic combinations of alleles of these genes: TT CC GG G/T; TT CC G/T TT; TT AA GG G/T; TT AA G/T G/T; TT AA G/T GG; TT AA G/T TT; TT A/C GG G/T; CC CC G/T G/T; CC AA GG GG; CC CC GG GG; CC CC GG TT; CC AA GG G/T—high risk of developing prostate cancer is predicted.
EFFECT: development of informative diagnostic method enables to identify patients with increased risk of prostate cancer on the basis of analysis of four single-nucleotide polymorphisms simultaneously.
1 cl, 5 dwg, 1 ex
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