FIELD: chemistry.
SUBSTANCE: invention relates to a novel method of obtaining 2-amino-2-cyanoadamantane derivatives of the given general formula 
, which can be applied as semi-products in a synthesis of biologically active amino acids, diamines and heterocyclic compounds. The method consists in a reaction of adamantanone-2 with derivatives of amines in the presence of potassium carbonate with heating. As amine derivatives used are aminonitriles from the group 2-N-cyclohexylamino-2-cyanopropane, 2-N-piperidino-2-cyanopropane, 2-N-benzylamino-2-cyanopropane with a molar ratio adamantanone-2:aminonitrile, equal to 1:1.2-1.5, and a temperature of 80-100°C. The process takes place in one stage for 60-70 min.
EFFECT: method makes it possible to obtain derivatives of 2-amino-2-cyanoadamantane of the given general formula with the high output.
3 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF OBTAINING 2-AMINO-2-CYANOADAMANTANE | 2013 |
|
RU2523462C1 |
| METHOD OF 2-AMINO-2-CYANOADAMANTANE TRANSAMINATION | 2013 |
|
RU2523463C1 |
| METHOD OF 2-N-PHENYLAMINO-2-CYANOADAMANTANE OR ITS DERIVATIVES PRODUCTION | 2007 |
|
RU2344124C1 |
| METHOD FOR PRODUCTION OF 2-AMINO-2-CYANOADAMANTANE OR DERIVATIVES THEREOF | 2006 |
|
RU2307123C1 |
| METHOD OF PRODUCING 2-AMINOMETHYL ALKYL(ARYL)AMINO ADAMANTANES | 2012 |
|
RU2484083C1 |
| METHOD OF PRODUCING 2-(2-ALKYL(DIALKYL)AMINO)ADAMANTYLALKYL(ARYL)KETONES | 2009 |
|
RU2408570C1 |
| METHOD OF PRODUCING CYCLOALKYLAMINES | 2010 |
|
RU2425828C1 |
| METHOD OF PRODUCING ALPHA-AMINOAMI | 0 |
|
SU1220568A3 |
| METHOD OF PREPARING 2-PERFLUOROALKYL-3-OXAZOLIN-5-ONE, AND INTERMEDIATE PRODUCTS | 1994 |
|
RU2134262C1 |
| METHOD OF PREPARING LACTAM | 1996 |
|
RU2167860C2 |
