METHOD OF OBTAINING 2-AMINO-2-CYANOADAMANTANE Russian patent published in 2014 - IPC C07C255/47 C07C253/30 C07D295/155 

FIELD: chemistry.

SUBSTANCE: invention relates to a novel method of obtaining 2-amino-2-cyanoadamantane derivatives of the given general formula , which can be applied as semi-products in a synthesis of biologically active amino acids, diamines and heterocyclic compounds. The claimed method consists in a reaction of adamantanone-2 with amines and a cyanogroup carrier in heating in the presence of potassium carbonate. As amines used are cyclohexylamine, 2-aminoethanol, aniline, piperidine, morpholine or piperazine, and as the cyanogroup carrier used is acetone cyanohydrin or 2-amino isobutyronitrile. The process is carried out in one stage for 1.5-2 h at 80-100°C. In the given general formula R=H, , -CH₂CH₂OH, C₆H₅, R-R₁=-(CH₂)₅-, -CH₂CH₂OCH₂CH₂-, -CH₂CH₂NHCH₂CH₂-.

EFFECT: method makes it possible to obtain derivatives of 2-amino-2-cyanoadamantane of the said general formula with the high output.

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