NOVEL AZETIDINE DERIVATIVES, USEFUL AS MODULATORS OF CORTICAL CATECHOLAMINERGIC NEUROTRANSMISSION Russian patent published in 2020 - IPC C07D205/04 A61K31/397 A61P25/00 A61P25/14 A61P25/18 A61P25/22 A61P25/28 

Abstract RU 2716814 C2

FIELD: chemistry.

SUBSTANCE: invention relates to organic chemistry, specifically to novel heterocyclic compounds of formula I or to their isomers or pharmaceutically acceptable salts, where R4 is F, R5 is H or C1-C4 alkyl substituted with 0 F, and n is 0, 1, 2 or 3. Also described is a pharmaceutical composition based on the compound of formula I and use of the compound of formula I as a monoamine level modulator.

formula I.

EFFECT: technical result is obtaining novel 3-benzyl-azetidine derivatives, useful for modulation of monoamine levels.

15 cl, 32 ex, 4 tbl

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RU 2 716 814 C2

Authors

Pettersson, Fredrik

Sonesson, Clas

Dates

2020-03-17Published

2016-05-20Filed