METHOD OF OBTAINING (E)-N-(3-TERT-BUTYL-5-(2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-yl)-2-METHOXY-STYRYL)PHENYL) METHANESULPHONAMIDE AND INTERMEDIATE COMPOUNDS FOR OBTAINING THEREOF Russian patent published in 2014 - IPC C07D239/54 C07C311/08

Abstract RU 2524573 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to a method of obtaining (e)-n-(4-(3-tert-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxy-styryl)phenyl) methanesulphonamide (compound I) or its salt, which includes reduction of N-(4-((3-tert-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl)ethinyl)phenyl)-methanesulphonamide (compound 6) with an application of at least one reducing agent, selected from a group, consisting of a source of hydrogen, silane and disilane, in the presence of at least one catalyst, base or solvent. Invention also relates to intermediate compounds, applicable for obtaining the compound I and its salts.

EFFECT: novel method of obtaining the compound I, useful in treatment of the hepatitis C virus is elaborated.

19 cl, 8 ex

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RU 2 524 573 C2

Authors

Napir Dzhejms Dzh.

Kalifano Zhan-Kristof

Bekker Kehlvin L.

Ju Su

Dates

2014-07-27—Published

2010-03-24—Filed