FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to compounds of formula
,
wherein R1 represents H, fluoro-, chloro- or C1-2alkoxygroup optionally substituted by one or more fluoro group; A represents O or S; R2 and R3 independently represent H or chloro; provided R2 and R3 are not positioned in relation to each other; R4 and R5 independently represent H or C1-4alkyl group; while X and Y independently represent O or CH2, provided X and Y are different. The invention also refers to a pharmaceutical composition possessing an antagonist activity in relation to type 1 melanin-concentrating hormone (MCH1) receptor and type 3 histamine receptor (H3) containing the compounds of formula I, a method of treating or preventing and to usage of the compounds of formula I.
EFFECT: compounds of formula I as type 1 melanin-concentrating hormone (MCH1) receptor and type 3 histamine receptor (H3) antagonists.
14 cl, 1 tbl, 2 dwg, 10 ex
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