FIELD: medicine.
SUBSTANCE: pharmaceutical antiangiogenic composition for treating eye diseases contains an active substance that is a fragment of one of recombinant polypeptides: endostatin fragment with an amino acid sequence from 1 to 49 or tumstatin fragment with an amino acid sequence from 69 to 95 or pigment epithelium-derived factor (PEDF) fragment with an amino acid sequence from 44 to 77 having stabilising ProGlyPro cluster on C-terminal, and a pharmaceutically acceptable carrier. The active substance and pharmaceutically acceptable carrier are found in the following proportions, wt %: active substance - 3.9×10-7 to 53×10-7 and pharmaceutically acceptable carrier - up to 100 wt %.
EFFECT: using this composition provides the antiangiogenic effect mediated by various biological targets at different stages of angiogenesis.
1 dwg, 3 tbl, 11 ex
