QUINOLONE ANALOGUES Russian patent published in 2009 - IPC C07D215/58 C07D401/04 C07D471/14 C07D513/14 A61K31/4745 A61P31/00 A61P35/00 

FIELD: chemistry.

SUBSTANCE: present invention pertains to new compounds with formula (1): and to their pharmaceutical salts, where B, X, A or V are not present, if Z¹, Z², Z³ or Z⁴ respectively represent N, and independently H, halogen atom, azido, R², CH₂R², SR², OR² or NR¹R², when Z¹, Z², Z³ or Z⁴ represent C. In each NR¹R², R¹ and R² together with N there can be formation of an optionally substituted piperidine, pyrrolidine, piperazine or morpholine ring. Z¹ represents N and Z², Z³ and Z⁴ represent C, or Z¹ and Z³ represent N and Z² and Z⁴ represent C. W together with N and Z form an optionally substituted thiazole, imidazole or pyrimidine ring, which is condensed with an optionally substituted ring, chosen from a group consisting of: or . U represents NR¹R², NR¹-(CR¹ ₂)_n-NR³R⁴, where in NR³R⁴, R³ and R⁴ together with N there can be formation of an optionally substituted piperidine, pyrrolidine, piperazine or morpholine ring. R¹ and R³ independently represent H or C_1-6alkyl. Each R² represents H or C_1-10alkyl, each optionally substituted with a halogen atom, or C_3-6cycloalkyl, aryl, heteroaryl or pyridine, pyrrolidine, piperazine or morpholine ring, where each ring is optionally substituted; or R² is optionally substituted with piperidine, pyrrolidine, pyridine, piperazine, pyrazine, morpholine or benzimidazole. R² represents H or C_1-10alkyl. Each R⁵ represents a substitute in any position in ring W, and is H, OR², amino, alkoxy, amido, halogen atom or cyano; or R⁵ represents C_1-6alkyl, -CONHR¹-, each optionally substituted with a halogen atom; or two adjacent R⁵ are linked with formation of a 5-6-member ring, an optionally substituted heterocyclic ring, chosen piperidine, pyrrolidine, piperazine or morpholine ring. n equals 1-6, and each optionally substituted part can be substituted with one or more halogens, OR², NR¹R² , carbamate, C_1-10alkyl, each optionally substituted with a halogen atom, C=O, cyano, nitro, COR², NR²COR², sulphonyl amides, NR²SOOR²; SR², SOR², COOR², CONR² ₂, OCOR², OCOOR² or OCONR² ₂. The invention also relates to pharmaceutical compositions, to the method of suppressing proliferation of cells and/or weakening cell proliferative breakdown, to the method of reducing microbe titre and/or weakening microbe infection, to the method of inducing death of cells and/or inducing apoptosis, to compounds, chosen from a group, to pharmaceutical compositions, as well as to the method of producing compounds with formula (1).

EFFECT: obtaining new biologically active compounds, which can suppress proliferation of cells and/or induce apoptosis.

41 cl, 113 ex, 12 tbl