FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to pharmaceutics, namely to a formulation for oral transmucosal administration which contains a lipid-lowering active substance specified in statins, fibrates or ezetimibe; an aqueous-alcohol solution consisting of water and 30° to 70° ethanol, wherein the above active substance is found in a stable and completely dissolved state with the pH value of the formulation falling within the range of 5.0 to 8.0. The invention also refers to a method for preparing the above formulation and using it for treating hyperlipidemia.
EFFECT: invention provides better efficacy for lower doses of the active substances (statins, fibrates and ezetimibe); their immediate bioavailability for hepatocytes and considerably reduced production of harmful metabolites that stands for eliminating the main side effects of these agents.
11 cl, 6 ex
