METHOD OF PRODUCING 2-HYDROXY-2-CARBOXYALKYLADAMANTANES Russian patent published in 2014 - IPC C07C59/11 C07C51/353 C07C51/02 

Abstract RU 2529190 C1

FIELD: chemistry.

SUBSTANCE: invention relates to a method of producing α-hydroxycarboxylic acids, particularly a novel method of producing 2-hydroxy-carboxyalkyladamantanes of general formula where R=H, CH3, which can be used as intermediate products in synthesis of adamantyl-containing amino acids and heterocyclic compounds. The method includes reacting adamantanone-2 with dilithium salts of acetic or propionic acid, obtained in situ by reacting lithium acetate or propionate with lithium hexamethyldisilylamide, obtained beforehand from hexamethyldisilazane and phenyllithium, in the medium of dry tetrahydrofuran at 20-45°C and molar ratio hexamethyldisilazane: lithium acetate or propionate: adamantanone-2 of 1.3-1.4:1.8-2.1:1.

EFFECT: wider range of compounds of the disclosed structural formula and obtaining products with high output and high degree of purity.

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RU 2 529 190 C1

Authors

Popov Jurij Vasil'Evich

Mokhov Vladimir Mikhajlovich

Tankabekjan Nazeli Arsenovna

Dates

2014-09-27Published

2013-04-23Filed