FIELD: chemistry.
SUBSTANCE: invention relates to a method of producing α-hydroxycarboxylic acids, particularly a novel method of producing 2-hydroxy-carboxyalkyladamantanes of general formula where R=H, CH3, which can be used as intermediate products in synthesis of adamantyl-containing amino acids and heterocyclic compounds. The method includes reacting adamantanone-2 with dilithium salts of acetic or propionic acid, obtained in situ by reacting lithium acetate or propionate with lithium hexamethyldisilylamide, obtained beforehand from hexamethyldisilazane and phenyllithium, in the medium of dry tetrahydrofuran at 20-45°C and molar ratio hexamethyldisilazane: lithium acetate or propionate: adamantanone-2 of 1.3-1.4:1.8-2.1:1.
EFFECT: wider range of compounds of the disclosed structural formula and obtaining products with high output and high degree of purity.
2 ex
Title |
Year |
Author |
Number |
METHOD OF PRODUCING 2,2-ADAMANTYLENE SPIROOXIRANE DERIVATIVES |
2013 |
- Popov Jurij Vasil'Evich
- Mokhov Vladimir Mikhajlovich
- Tankabekjan Nazeli Arsenovna
|
RU2529025C1 |
(E)-3-[2-N-BUTYL-1-{(4-CARBOXYPHENYL)-METHYL}-1H-IMIDAZOLE-5- -YL]-2-(2-THIENYL)-METHYL-2-PROPENOIC ACID METHANESULFONATE, METHOD OF ITS SYNTHESIS, PHARMACEUTICAL COMPOSITION BASED ON THEREOF |
1992 |
- Richard Makkallok Kinen
- Dzhozef Vajnshtok
|
RU2124513C1 |
METHOD OF RACEMIZATION OF OPTICALLY PURE OR ENRICHED PIPERAZIN-2-TERT-BUTYLCARBOXAMIDE SUBSTRATE AND RACEMIC 2-TERT-BUTYLCARBOXAMIDE-4-(3-PICOLYL)PIPERAZINE |
1995 |
- Kaj Rossen
- Dehvid Askin
- Pol Rejder
- Richard Dzh.Varsolona
- Ral'F Volante
|
RU2135482C1 |
COMPOUNDS OF 2-AMINOCARBOXYLIC ACID SUBSTITUTED WITH 5-ARYL- -ISOXAZOLE-4-YL AND PHARMACEUTICAL COMPOSITION ON THEIR BASE |
1994 |
- Mol'Tsen Lens Sibille
- Falk Ehrik
- Bogeso Klaus Peter
- Krogsgord-Larsen Povl
|
RU2138488C1 |
QUINOLINE DERIVATIVES, PARTICULARLY 6,7-SUBSTITUTED 1-(2-CHLOROQUINOLIN-3-YL)-4-DIMETHYLAMINO-2-(NAPHTHALEN-1-YL)-1-PHENYLBUTAN-2-OLS, METHOD FOR PRODUCTION THEREOF AND USE OF COMPOUNDS TO TREAT INFECTIOUS MYCOBACTERIAL DIESEASES, PARTICULARLY TUBERCULOSIS |
2013 |
- Nazarenko Anna Borisovna
- Fedorov Vladimir Egorovich
- Il'In Vadim Igorevich
- Omel'Kov Anton Vladimirovich
|
RU2530493C1 |
|
0 |
- Rajmond Armond Firstoun
- Lovdzi Dadi Kama
- Barton Grant Kristensen
|
SU467521A3 |
DILITHIUM INITIATOR FOR ANIONIC (CO)POLYMERIZATION, METHOD FOR PREPARING THE SAME, METHOD FOR PRODUCING DIENE RUBBERS BASED ON THE INITIATOR |
2014 |
- Budeeva Anna Viktorovna
- Shirin Kirill Nikolaevich
|
RU2667061C1 |
2-AMINOINDANES AS SELECTIVE LIGANDS OF DOPAMINE |
1996 |
- Artur G. Romero
- Dzheffri A. Lejbi
|
RU2161601C2 |
METHOD FOR PREPARING PHENYLALANINE DERIVATIVES AND THEIR SEMI-FINISHED PRODUCTS |
2003 |
- Inoueh Isao
- Kuroda Toru
- Esioka Rjuzo
|
RU2280641C2 |
METHOD OF SYNTHESIS OF LEUKOTRIENE ANTAGONISTS, DICYCLOHEXYL-AMINE SALT, METHODS OF PREPARING CRYSTALLINE SODIUM SALT AND 1-(MERCAPTOMETHYL)-CYCLOPROPANE ACETIC ACID, CRYSTALLINE COMPOUNDS |
1994 |
- Makhadevan Bkhupati
- Dzhejms M.Maknamara
- Daniehl R.Sidler
- Ral'F P.Volante
- Dzhejms Dzh.Bergan
|
RU2140909C1 |