QUINOLINE DERIVATIVES, PARTICULARLY 6,7-SUBSTITUTED 1-(2-CHLOROQUINOLIN-3-YL)-4-DIMETHYLAMINO-2-(NAPHTHALEN-1-YL)-1-PHENYLBUTAN-2-OLS, METHOD FOR PRODUCTION THEREOF AND USE OF COMPOUNDS TO TREAT INFECTIOUS MYCOBACTERIAL DIESEASES, PARTICULARLY TUBERCULOSIS Russian patent published in 2014 - IPC C07D491/56 A61K31/4738 A61P31/06 

Abstract RU 2530493 C1

FIELD: chemistry.

SUBSTANCE: invention relates to novel derivatives of 1-(2-chloroquinolin-3-yl)-4-dimethylamino-2-(naphthalen-1-yl)-1-phenylbutan-2-ol of general formula I or their pharmaceutically acceptable salts with acids, where R1 denotes H, R2+R3 denotes -O-(CH2)n-O-, where n=1-2, which forms additional dioxane and 1,3-dioxolane rings. The invention also relates to a method of producing a compound of formula I and to use of the compound of formula I in treating infectious mycobacterial diseases.

EFFECT: obtaining novel compounds with useful biological activity.

4 cl, 2 tbl, 3 ex

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RU 2 530 493 C1

Authors

Nazarenko Anna Borisovna

Fedorov Vladimir Egorovich

Il'In Vadim Igorevich

Omel'Kov Anton Vladimirovich

Dates

2014-10-10Published

2013-04-22Filed