NEW DRUG PREPARATION FOR INHIBITING AGGREGATION OF PROTEINS INVOLVED IN DISEASES RELATED TO AGGREGATION OF PROTEINS, AND NEURODEGENERATIVE DISEASES Russian patent published in 2014 - IPC C07D231/06 C07D231/12 C07D405/04 C07D233/22 C07D261/08 C07D207/333 C07D271/06 A61K31/415 A61P25/28 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to a compound presented by formula (E) , wherein X, Y and L are independently non-directionally specified in -C(R¹)(R²)-, -C(R³)=, -N(R⁴)-, -N= and -O-; M and Z are independently non-directionally specified in ; ---- means an optional double bond; R¹, R², R³, R⁴ and R⁶ are independently specified in hydrogen; C_1-4 alkyl; group -C_1-4 alkylene-halogen; group -C_1-4 alkylene-OH; Hal is specified in F, Cl, Br and I; R^E1 and R^E2 are attached to neighbouring carbon atoms, and R^E1 and R^E2 together non-directionally form the structure -T-(CR^E7R^E8)_n-V-, wherein T is specified in CR^E9R^E10 and O or NH, and V is specified in CR^E9R^E10 and O or NH, as well as respective structures comprising a double bond; at least one of T or V represents O or N; R^E7 and R^E8 represent H or F; R^E9 and R^E10 represent H; n takes on the values of 1 to 2; R^E3 represents C_1-6 alkyl group; m takes on the values of 0 or 1; R^E4 represents a halogen atom; p takes on the values of 0 or 1; as well as to pharmaceutical diagnostic compositions of the above compound.

EFFECT: preparing the new pharmaceutical compounds.

41 cl, 17 dwg, 2 tbl, 17 ex