WATER-SOLUBLE DERIVATIVES OF 3,5-DIPHENYLDIAZOLE COMPOUNDS Russian patent published in 2022 - IPC C07F9/11 A61P25/28 A61K31/675 

Abstract RU 2764131 C2

FIELD: medicine.

SUBSTANCE: present invention relates to a compound represented by one of following isomeric structures Ia and Ib, which is used for the treatment of prevention of diseases related to protein aggregation, to a pharmaceutical composition based on it, to a method for the treatment or prevention of diseases related to protein aggregation using the claimed compound, as well as to the use of the claimed compound or the composition based on it for the production of a drug:

, where Y is N, and Z is -CH-; where either X is , and Hal is halogen selected from chlorine or bromine, or X is , and Hal is bromine; where each R is independently hydrogen or cation selected from sodium, lithium, potassium, ammonium or a protonated form of ethanolamine, choline, lysine, meglumine, piperazine and tromethamine.

EFFECT: obtaining a compound for the treatment or prevention of a disease related to protein aggregation.

16 cl, 4 dwg, 12 ex

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RU 2 764 131 C2

Authors

Giese, Armin

Schmidt, Felix

Griesinger, Christian

Leonov, Andrei

Ryazanov, Sergey

Dates

2022-01-13Published

2016-12-14Filed