METHOD FOR SIMULATING ALLOXAN DIABETES Russian patent published in 2014 - IPC G09B23/28 

FIELD: medicine.

SUBSTANCE: invention refers to experimental medicine and can be used for examining diabetes mellitus, as well as in developing new methods of treating changes caused by type I diabetes mellitus. That is ensured by simulating alloxan diabetes in white outbread rats. Developing subcompensated diabetes mellitus is ensured by administering an alloxan solution in the rats intermittently intraperitoneally on an empty stomach, successively in doses of 5 mg/100 g, 7 mg/100 g and 5 mg/100 g of the animal's weight every 7 days, and developing decompensated diabetes mellitus is provided by three administrations of the alloxan solution in a dose of 10 mg/100 g every second day.

EFFECT: method provides higher probability of successful repetition and predictability of stimulating this disease by modifying the model corresponding to its subcompensated and decompensated forms.

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