METHOD FOR SIMULATING COMBINED RADIATION INJURIES INVOLVING WHOLE-BODY GAMMA- AND LOCAL BETA-RADIATION Russian patent published in 2014 - IPC G09B23/28 

FIELD: medicine.

SUBSTANCE: invention can be used for studying pathogenesis mechanisms of combined radiation injuries (CRIs) including the mutual burdening phenomenon, as well as testing new methods and aids for preventing and treating CRIs. That is ensured by the CRI simulation by the sequential radiation exposure on rats. Total γ-radiation is first provided. That is followed by local beta-radiation covering a hair-free area of the animal's skin area isolated by a screen. A degree III-a burns are simulated by the use of beta-radiation in doses 30 and 60 Gy generated by a contact ionising radiation source having an activity of 24.3 mKi (900 MBq), an average radiant energy of E_av=1.4 MeV at a dose rate at the skin surface of 2.1 Gy/min triple attenuated through the skin thickness.

EFFECT: method enables the experimental reproduction of the radiation disease and the degree III-a superficial radiation burns equal in severity, and studying the effect of superficial skin injuries on the clinical course and outcomes of CRIs depending on the total radiation doses selected.

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