FIELD: chemistry.
SUBSTANCE: invention relates to 3-phenoxymethyl-pyrrolidines of formula
,
given below, where R1 stands for -C2-6alkyl, -C3-8cycloalkyl, optionally substituted with 1 or 2 fluorine atoms, -C2-6alkenyl and -C2-6alkinyl; R2-R6 independently stand for hydrogen, halogen, -C1-6alkyl, -CF3, -O-C1-6alkyl, -CN, -C(O)-C1-6alkyl, -S-C1-6alkyl,-C3-8cycloalkyl and -NO2; or R4 and R5 are taken together with the formation of -CH=CH-CH=CH-; or R5 and R6 are taken together with the formation of -CH-CH=CH-CH-; on condition that when R1 stands for ethyl, R2 stands for fluorine-, R4 stands for chlorine-, R5 stands for hydrogen, and R6 stands for hydrogen, then R3 does not stand for fluorine- or chlorine-; or to their pharmaceutically acceptable salts. The compounds of formula (I) are serotonin and norepinephrine reuptake inhibitors. Described is a method of their obtaining and intermediate compounds, used for obtaining the formula (I) compounds.
EFFECT: improved properties of the compounds.
28 cl, 26 ex
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