Show metadata Hide metadata

(19)

(11)

2 535 676

(13)

(51)

IPC

C07F9/54(2006-01-01)

A61K8/55(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2013137092/04, 2013-08-06

(24)

Start date

2013-08-06

(22)

Actual filing date

2013-08-06

(45)

Published

2014-12-20

(72)

Inventor

Nevinskij Georgij AleksandrovichZakharova Ol'Ga DmitrievnaGorjunov Leonid IvanovichZhivet'Eva Svetlana IvanovnaShtejngarts Vitalij Davidovich

(73)

Holder

Federal'Noe Gosudarstvennoe Bjudzhetnoe Uchrezhdenie Nauki Institut Khimicheskoj Biologii I Fundamental'Noj Meditsiny Sibirskogo Otdelenija Rossijskoj Akademii Nauk So Ran)Federal'Noe Gosudarstvennoe Bjudzhetnoe Uchrezhdenie Nauki Novosibirskij Institut Organicheskoj Khimii Im. N.N. Vorozhtsova Sibirskogo Otdelenija Rossijskoj Akademii Nauk So Ran)

PHOSPHORUS-CONTAINING FLUORINATED 1,4-NAPHTHOQUINONE DERIVATIVES, POSSESSING CYTOTOXIC ACTIVITY WITH RESPECT TO HUMAN CANCER CELLS IN CULTURE Russian patent published in 2014 - IPC C07F9/54 A61K8/55 A61P35/00

Abstract RU 2535676 C1

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to novel fluorinated 1,4-naphthoquinone derivatives of general formula , where 1 R=C₆H₅, X=F; 2 R=2, 5-F₂C₆H₃, X=F; 3 R=CH₃, X=F; 4 R=C₆H₅, X, , possessing cytotoxic activity with respect to cancer cells, which can be applied in medicine.

EFFECT: claimed are novel compounds with anti-cancer activity for therapy of malignant neoplasms.

1 dwg, 3 tbl, 5 ex

Similar patents RU2535676C1

Title	Year	Author	Number
ALKYLATING FLUORINATED 1,4-NAPHTHOQUINONE DERIVATIVES HAVING CYTOTOXIC EFFECT ON HUMAN CANCER CELLS IN CULTURE	2012	Nevinskij Georgij Aleksandrovich Zakharova Ol'Ga Dmitrievna Gorjunov Leonid Ivanovich Troshkova Nadezhda Mikhajlovna Shtejngarts Vitalij Davidovich	RU2499789C1
FLUORINATED 1,4-NAPHTHOQUINONE DERIVATIVES HAVING CYTOTOXIC EFFECT ON HUMAN CANCER CELLS IN CULTURE	2010	Nevinskij Georgij Aleksandrovich Zakharova Ol'Ga Dmitrievna Gorjunov Leonid Ivanovich Troshkova Nadezhda Mikhajlovna Shtejngarts Vitalij Davidovich	RU2443678C1
FLUORINATED 1,4-NAPHTHOQUINONE DERIVATIVES HAVING CYTOTOXIC EFFECT ON HUMAN CANCER CELLS IN CULTURE	2008	Nevinskij Georgij Aleksandrovich Zakharova Ol'Ga Dmitrievna Gorjunov Leonid Ivanovich Troshkova Nadezhda Mikhajlovna Shtejngarts Vitalij Davidovich	RU2387635C1
FRACTION OF DNA-HYDROLYSE SECRETORY IMMUNOGLOBULINS OF CLASS A, WITH SELECTIVE APOPTOTIC ACTIVITY IN RELATION TO HUMAN CANCER CELLS	2015	Nevinskij Georgij Aleksandrovich Buneva Valentina Nikolaevna	RU2605321C1
LABDANE-TYPE 6-HYDROXYNAPHTHOQUINONES, HAVING CYTOTOXIC ACTIVITY ON HUMAN TUMOUR CELLS	2012	Shul'Ts Ehl'Vira Ehduardovna Mironov Maksim Evgen'Evich Pokrovskij Mikhail Andreevich Sherman Ksenija Mikhajlovna Pokrovskij Andrej Georgievich Tolstikov Genrikh Aleksandrovich	RU2479582C1
DIPROPIONATE BETULIN COMPOSITION	2013	Kuznetsova Svetlana Alekseevna Shakhtshnejder Tat'Jana Petrovna Mikhajlenko Mikhail Aleksandrovich Maljar Jurij Nikolaevich Boldyrev Vladimir Vjacheslavovich	RU2541153C1
(17S)-N-BENZYL-5-((3Β-ACETOXY-28-NOR-URS-12-ENE)-17-YL)-1,3,4-OXADIAZOL-2-AMINE, HAVING SELECTIVE CELL CYTOTOXICITY BREAST CANCER MCF-7	2019	Popov Sergej Aleksandrovich Semenova Mariya Dmitrievna Shults Elvira Eduardovna Frolova Tatyana Sergeevna	RU2708400C1
RECOMBINANT PLASMID DNA pFLAG-sc14D5a-Rm7 ENSURING SYNTHESIS OF HYBRID PROTEIN sc14D5a-Rm7, BACTERIA STRAIN Escherichia coli - PRODUCER OF HYBRID PROTEIN sc14D5a-Rm7, AND HYBRID PROTEIN sc14D5a-Rm7, COMBINING PROTEIN E OF TICK-BORNE ENCEPHALITIS MICE AND HAVING BIO-LUMINESCENCE ACTIVITY	2014	Frank Ljudmila Alekseevna Tikunova Nina Viktorovna Burakova Ljudmila Petrovna Bajkov Ivan Konstantinovich Kudrjavtsev Aleksandr Nikolaevich Morozova Vera Vital'Evna	RU2565545C1
TRITERPENE ANTI-TUMOUR DRUG PRODUCED VIA MODIFICATION OF GLYCYRRHETIC ACID	2009	Salomatina Oksana Vladimirovna Salakhutdinov Nariman Faridovich Tolstikov Genrikh Aleksandrovich Logashenko Evgenija Borisovna Zenkova Marina Arkad'Evna Vlasov Valentin Viktorovich	RU2401273C1
METHOD OF PRODUCING 6,7-SUBSTITUTED 2,3,5,8-TETRAHYDROXY-1,4-NAPHTHOQUINONES (SPINAZARINS)	2012	Polonik Nikita Sergeevich Polonik Sergej Georgievich	RU2478607C1

RU 2 535 676 C1

Authors

Nevinskij Georgij Aleksandrovich

Zakharova Ol'Ga Dmitrievna

Gorjunov Leonid Ivanovich

Zhivet'Eva Svetlana Ivanovna

Shtejngarts Vitalij Davidovich

Dates

2014-12-20—Published

2013-08-06—Filed