FLUORINATED 1,4-NAPHTHOQUINONE DERIVATIVES HAVING CYTOTOXIC EFFECT ON HUMAN CANCER CELLS IN CULTURE Russian patent published in 2010 - IPC C07C225/30 C07D295/73 C07D213/20 C07C50/32 C07C313/20 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to an agent, which is in form of fluorinated 1,4-naphthoquinone derivatives of general formula (I) which have cytotoxic effect on human cancer cells in a culture. In general formula (I) 1) R₁=NHC(CH₃)₃, R₂, R₃=F; 2) R₁=NHCH₂CH₂SCH₃, R₂, R₃=F; 3) R₁=N(CH₂CH₂)₂, R₂, R₃=F; 4) R₁=N(CH₂CH₂)₂, R₂, R₃=F; 5) R₁=NHCH₂CH₂CH₂CH₃, R₂, R₃=F; 6) R₁=NHC₆H₅R₂, R₃=F; 7) R₁=H(CH₃)CH₂CH₂OH, R₂, R₃=F; 8) R₁, R₃=NHCH₂CH₂CH₂CH₃, R₂=F; 9) R₁=N(CH₂CH₂OH)₂, R₂, R₃=F; 10) R₁=NHC₆H₅, R₂=CH₃, R₃=F; 11) R₁=OCH₃, R₂, R₃=F; 12) R₁=NH(CH₂)₂SS(CH₂)₂NH(2-pentafluoro-1,4-naphthoqunonyl), R₂, R₃=F; 13) R₁=NHC₂H₅, R₂, R₃=F; 14) R₁=N+C₅H₅, R₂=O; R₃=F; 15) R₁=NHCH₂CH₂OH, R₂,R₃=F; 16)R₁, R₂=OCH₃, R3=F.

EFFECT: proposed compounds can be used in medicine as a base for designing drug formulations of preparations used in malignant growth therapy.

2 dwg, 4 tbl, 3 ex