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2 499 789

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IPC

C07C50/12(2006-01-01)

C07C50/24(2006-01-01)

C07C50/32(2006-01-01)

C07C43/225(2006-01-01)

C07C323/09(2006-01-01)

C07C323/22(2006-01-01)

A61P35/00(2006-01-01)

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Application

2012146742/04, 2012-11-01

(24)

Start date

2012-11-01

(22)

Actual filing date

2012-11-01

(45)

Published

2013-11-27

(72)

Inventor

Nevinskij Georgij AleksandrovichZakharova Ol'Ga DmitrievnaGorjunov Leonid IvanovichTroshkova Nadezhda MikhajlovnaShtejngarts Vitalij Davidovich

(73)

Holder

Federal'Noe Gosudarstvennoe Bjudzhetnoe Uchrezhdenie Nauki Institut Khimicheskoj Biologii I Fundamental'Noj Meditsiny Sibirskogo Otdelenija Rossijskoj Akademii Nauk So Ran)Federal'Noe Gosudarstvennoe Bjudzhetnoe Uchrezhdenie Nauki Novosibirskij Institut Organicheskoj Khimii Im. N.N. Vorozhtsova Sibirskogo Otdelenija Rossijskoj Akademii Nauk So Ran)

ALKYLATING FLUORINATED 1,4-NAPHTHOQUINONE DERIVATIVES HAVING CYTOTOXIC EFFECT ON HUMAN CANCER CELLS IN CULTURE Russian patent published in 2013 - IPC C07C50/12 C07C50/24 C07C50/32 C07C43/225 C07C323/09 C07C323/22 A61P35/00

Abstract RU 2499789 C1

FIELD: chemistry.

SUBSTANCE: invention relates to novel fluorinated 1,4-naphthoquinone derivatives which contain alkylating groups of general formula (I), where R¹, R²=SCH₂CH₂Cl, or R¹, R²=OCH₂CH₂Cl, or R¹=OCH₂CH₂Cl, R²=F, or R¹=SCH₂CH₂Cl, R²=OCH₃, which have cytotoxic effect on human cancer cells in a culture.

EFFECT: high activity of the compound.

1 dwg, 2 tbl, 5 ex

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RU 2 499 789 C1

Authors

Nevinskij Georgij Aleksandrovich

Zakharova Ol'Ga Dmitrievna

Gorjunov Leonid Ivanovich

Troshkova Nadezhda Mikhajlovna

Shtejngarts Vitalij Davidovich

Dates

2013-11-27—Published

2012-11-01—Filed