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2 443 678

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IPC

C07C229/18(2006-01-01)

C07C229/14(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2010142521/04, 2010-10-18

(24)

Start date

2010-10-18

(22)

Actual filing date

2010-10-18

(45)

Published

2012-02-27

(72)

Inventor

Nevinskij Georgij AleksandrovichZakharova Ol'Ga DmitrievnaGorjunov Leonid IvanovichTroshkova Nadezhda MikhajlovnaShtejngarts Vitalij Davidovich

(73)

Holder

Uchrezhdenie Rossijskoj Akademii Nauk Institut Khimicheskoj Biologii I Fundamental'Noj Meditsiny Sibirskogo Otdelenija Ran So Ran)Novosibirskij Institut Organicheskoj Khimii Im. N.N. Vorozhtsova Sibirskogo Otdelenija Rossijskoj Akademii Nauk So Ran)

FLUORINATED 1,4-NAPHTHOQUINONE DERIVATIVES HAVING CYTOTOXIC EFFECT ON HUMAN CANCER CELLS IN CULTURE Russian patent published in 2012 - IPC C07C229/18 C07C229/14 A61P35/00

Abstract RU 2443678 C1

FIELD: chemistry.

SUBSTANCE: invention relates to novel fluorinated derivatives of 1,4-naphthoquinone of general formula (II), having cytotoxic effect on human cancer cells in a culture. In formula (II) R = NHCH₂COOH, NHCH₂COOC₂H₅, NH(CH₂)₅COOH, NH(CH₂)₃COOH, NH(CH₂)₂COOH, OOC(CH₂)₃NH₂.

EFFECT: disclosed compounds can be used in medicine for therapy of malignant growths.

1 dwg, 4 tbl, 5 ex

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RU 2 443 678 C1

Authors

Nevinskij Georgij Aleksandrovich

Zakharova Ol'Ga Dmitrievna

Gorjunov Leonid Ivanovich

Troshkova Nadezhda Mikhajlovna

Shtejngarts Vitalij Davidovich

Dates

2012-02-27—Published

2010-10-18—Filed