FIELD: biochemistry.
SUBSTANCE: invention relates to biochemistry. Purposed a fraction of DNA-hydrolyse secretory immunoglobulins of class A (sIgA), having molecular weight 380 kDa, processing selective apoptotic activity in relation to human cancer cells, extracted from milk of healthy donors by affinity chromatography on protein-A-sepharose, then ion-exchange chromatography on DEAE-cellulose, then by affinity chromatography on DNA-cellulose.
EFFECT: invention enables to inhibit cancer cell growth on the way of apoptosis without inducing death of normal (non-tumorous) cells.
1 cl, 7 dwg, 1 tbl, 3 ex
Title | Year | Author | Number |
---|---|---|---|
PEPTIDE POSSESSING APOPTOTIC ACTIVITY WITH RESPECT TO HUMAN CANCER CELLS | 2006 |
|
RU2317304C1 |
RECOMBINANT PLASMID DNA pFK2 PROVIDING SYNTHESIS OF RECOMBINANT PEPTIDE BEING HUMAN KAPPA CASEIN FRAGMENT ANALOGUE, METHOD FOR PREPARING RECOMBINANT PEPTIDE, AND RECOMBINANT PEPTIDE, HUMAN KAPPA CASEIN FRAGMENT ANALOGUE EXHIBITING APOPTOTIC ACTIVITY IN RELATION TO MALIGNANT CELLS | 2009 |
|
RU2401307C1 |
RECOMBINANT PLASMID pET-15b_T3_RL DNA PROVIDING SYNTHESIS OF RECOMBINANT FUSION PROTEIN CONSISTING OF TUMOR-SPECIFIC PEPTIDES AND ANTITUMOR PEPTIDE RL2, AND RECOMBINANT FUSION PROTEIN POSSESSING ANTI-TUMOR ACTIVITY AGAINST HUMAN BREAST CANCER | 2016 |
|
RU2619053C1 |
RECOMBINANT PLASMID pET-15b_T1_RL DNA PROVIDING SYNTHESIS OF RECOMBINANT FUSION PROTEIN CONSISTING OF TUMOR-SPECIFIC PEPTIDES AND ANTITUMOR PEPTIDE RL2, AND RECOMBINANT FUSION PROTEIN POSSESSING CYTOTOXIC ACTIVITY AGAINST CANCER CELLS AND TARGETED PROPERTIES AGAINST TUMOR TISSUE | 2016 |
|
RU2619050C1 |
METHOD FOR EXTRACTING AND PURIFYING RECOMBINANT PROTEIN, AN ANALOGUE OF A HUMAN KAPPA-CASEIN FRAGMENT HAVING CYTOTOXIC ACTIVITY TOWARDS HUMAN CANCER CELLS | 2018 |
|
RU2693251C1 |
RECOMBINANT EL1 PEPTIDE HAVING CYTOTOXIC ACTIVITY RELATIVE TO HUMAN CANCER CELLS | 2017 |
|
RU2683221C1 |
NOVEL ANTIPROLIFERATIVE PROTEIN FROM BACILLUS THURINGIENSIS VARIETAS THURINGIENSIS | 1996 |
|
RU2178798C2 |
AGENT STIMULATING APOPTOSIS OF HUMAN LEUKAEMIA CELLS | 2007 |
|
RU2360692C1 |
ANTITUMOR AGENTS BASED ON MACRO- AND MICROELEMENT-CONTAINING POLYGALACTURONATES (OPTIONS) | 2022 |
|
RU2792613C1 |
STRAIN OF HYBRID CULTIVATED CELLS OF ANIMALS Mus Musculus, PRODUCING MONOCLONAL ANTIBODIES, SPECIFIC TO PEPTIDE, WHICH POSSESSES APOPTOTIC ACTIVITY WITH RESPECT TO CANCER CELLS | 2009 |
|
RU2402605C1 |
Authors
Dates
2016-12-20—Published
2015-07-16—Filed