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2 536 870

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IPC

C07D405/06(2006-01-01)

A61P1/04(2006-01-01)

(21) (22)

Application

2013147548/04, 2013-10-24

(24)

Start date

2013-10-24

(22)

Actual filing date

2013-10-24

(45)

Published

2014-12-27

(72)

Inventor

Shul'Ts Ehl'Vira EhduardovnaPatrushev Sergej SergeevichDolgikh Margarita PetrovnaTolstikova Tat'Jana Genrikhovna

(73)

Holder

Federal'Noe Gosudarstvennoe Bjudzhetnoe Uchrezhdenie Nauki Novosibirskij Institut Organicheskoj Khimii Im. N.N. Vorozhtsova Sibirskogo Otdelenija Rossijskoj Akademii Nauk So Ran)

13-E-(2,4-DIOXO-1,2,3,4-TETRAHYDROPYRIMIDIN-5-YL) EUDESMANOLIDES HAVING ANTIULCER ACTIVITY Russian patent published in 2014 - IPC C07D405/06 A61P1/04

Abstract RU 2536870 C1

FIELD: chemistry.

SUBSTANCE: invention relates to novel amides of Lambert acids (13-E-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl) eudesmanolides) of formula (Ia-c), having antiulcer activity. In formula (Ia-c)

where R¹=R²=Me, X=H (Ia) or R¹=R²=Me,

R¹=R²=C₇H₁₅, R²=H, X=H (Ic). The compounds relate to class 3 moderately hazardous substances.

EFFECT: compounds exhibit marked antiulcer activity on an indomethacin ulcer model.

1 tbl, 6 ex

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RU 2 536 870 C1

Authors

Shul'Ts Ehl'Vira Ehduardovna

Patrushev Sergej Sergeevich

Dolgikh Margarita Petrovna

Tolstikova Tat'Jana Genrikhovna

Dates

2014-12-27—Published

2013-10-24—Filed