DIFFERENTIAL DIAGNOSTIC TECHNIQUE FOR CERVICAL DYSPLASIA AND CERVICAL CANCER Russian patent published in 2015 - IPC G01N33/50 

FIELD: medicine.

SUBSTANCE: invention refers to medicine and aims at differential diagnostics of cervical dysplasia and cervical cancer. The cervical biopsy material is taken. If a cytological examination shows cervical dysplasia, RNA is recovered from the tissue sample, and iRNA expression of the c-fos gene is analysed in relation to the TATA-related protein (TBP) with using qualitative PCR. If the ratio of iRNA expression of the c-fos gene to TBP iRNA is from 109 to 145 relative units, severe dysplasia is diagnosed; if the related ratio falls within the range of 18 to 35 standard units, pre-invasive cervical cancer (cancer in situ) is diagnosed; the ratio falling within the range of 148 to 208 relative units enables diagnosing squamous microinvasive cervical cancer; the derived value exceeding 208 standard units, squamous invasive cervical cancer is diagnosed.

EFFECT: presented invention enables diagnosing the pre-cancer processes of cervical cancer effectively and differentiating the early stages of squamous cancer.

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