DIAGNOSTIC TECHNIQUE FOR HYPERPROLIFERATIVE CONDITIONS AND METHOD FOR ASSESSING RISK OF CERVICAL CANCER ACCOMPANYING CERVICAL INTRAEPITHELIAL NEOPLASIA AND PAPILLOMA VIRUS CARRIER STATE BY DETERMINIG MRNA OF FUNCTIONAL HUMAN GENE COMPLEX Russian patent published in 2014 - IPC G01N33/50 C12Q1/68 

FIELD: medicine.

SUBSTANCE: invention can be used to assess a risk of cervical cancer accompanying cervical intraepithelial neoplasia and a human papilloma virus (HPV) carrier state in fertile females. That is ensured by sampling cells from the exocervical surface to recover RNA and measuring the gene mRNA expression levels: MKI67, CDKN2A, PGR, BAX. Relating the mRNA expression levels provides calculating a linear discriminant function (LDF): LDF=1.2*lg[CDKN2A]/[BAX]-lg[PGR]/[MKI67]-1, wherein [CDKN2A]/[BAX] is the relation of the CDKN2A and BAX mRNA expression levels, [PGR]/[MKI67] is the relation of the progesterone receptor and MKI67 mRNA expression levels, and if LDF≤0, a low risk of neoplastic transformation is stated; LDF>0 shows a higher risk of neoplastic transformation.

EFFECT: method enables assessing a risk of cervical cancer by the representation of reference genes mRNAs.

2 dwg, 1 ex