METHOD OF EVALUATING IMMUNOSUPPRESSIVE PROPERTIES OF HUMAN MESENCHYMAL STROMAL CELLS Russian patent published in 2015 - IPC C12N5/71 

Abstract RU 2539750 C2

FIELD: medicine.

SUBSTANCE: invention relates to field of medicine, molecular biology and biopharmaceutics. Method of determining immunosuppressive properties of human mesenchymal stromal cells by measuring expression level of molecule HLA-DR on the surface of cell membranes and measuring level expression of molecules IDO, iNOS and COX-2 in cells. As criterion of evaluation serves double increase of level of expression of HLA-DR on the surface of membranes MSC and/or mRNA genes IDO, iNOS and COX-2 in cells.

EFFECT: invention can be applied for evaluation of immunosuppressive properties of cells for diagnostic purposes.

6 dwg, 5 ex

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RU 2 539 750 C2

Authors

Tkachuk Vsevolod Arsen'Evich

Suzdal'Tseva Julija Gennad'Evna

Rubtsov Jurij Petrovich

Gorjunov Kirill Vladimirovich

Dates

2015-01-27Published

2013-04-09Filed