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2 539 764

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IPC

C12N15/63(2006-01-01)

C12N15/86(2006-01-01)

C12N15/12(2006-01-01)

C12N15/52(2006-01-01)

A61K48/00(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2013114741/10, 2013-04-02

(24)

Start date

2013-04-02

(22)

Actual filing date

2013-04-02

(45)

Published

2015-01-27

(72)

Inventor

Sverdlov Evgenij DavidovichAlekseenko Irina Vasil'EvnaVinogradova Tat'Jana ViktorovnaKopantsev Evgenij PavlovichKorobko Igor' ViktorovichKostina Marija BorisovnaMonastyrskaja Galina SergeevnaPleshkan Viktor ViktorovichSass Aleksandr ViktorovichUspenskaja Natalija JakovlevnaChernov Igor' Pavlovich

(73)

Holder

Obshchestvo S Ogranichennoj Otvetstvennost'Ju

MULTIPURPOSE CANCER-SPECIFIC PROMOTERS AND USING THEM IN ANTI-CANCER THERAPY Russian patent published in 2015 - IPC C12N15/63 C12N15/86 C12N15/12 C12N15/52 A61K48/00 A61P35/00

Abstract RU 2539764 C2

FIELD: medicine.

SUBSTANCE: invention refers to biotechnology, in particular to tumour-specific promoters, and can be used in the anti-cancer therapy. There are constructed the broad-spectrum tumour-specific promoters providing the therapeutic gene expression inside a cancer cell. The invention also involves expression cassettes, expression vectors, pharmaceutical compositions, methods of treating cancer and using the expression cassettes and vectors.

EFFECT: promoters of the present invention provide a high expression level of the operatively linked therapeutic gene in the cancer cells of different origin, wherein the normal cell expression is absent or low.

29 cl, 19 dwg, 4 tbl, 20 ex

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RU 2 539 764 C2

Authors

Sverdlov Evgenij Davidovich

Alekseenko Irina Vasil'Evna

Vinogradova Tat'Jana Viktorovna

Kopantsev Evgenij Pavlovich

Korobko Igor' Viktorovich

Kostina Marija Borisovna

Monastyrskaja Galina Sergeevna

Pleshkan Viktor Viktorovich

Sass Aleksandr Viktorovich

Uspenskaja Natalija Jakovlevna

Chernov Igor' Pavlovich

Dates

2015-01-27—Published

2013-04-02—Filed