METHOD FOR PRODUCING NANOPARTICLES WITH A METAL PARTICLE CONTAINING IRON OXIDE, WHEREWITH ONE OR MULTIPLE HYDROPHILIC LIGANDS ARE IN A COORDINATE BOND Russian patent published in 2022 - IPC C01G49/02 B82Y40/00 A61K49/06 

FIELD: chemistry.

SUBSTANCE: invention can be used in manufacturing non-toxic contrast MRI agents. Nanoparticles of iron oxide, with the surface whereof a hydrophobic ligand - oleic and/or stearic acid is in a coordinate bond, undergo an interaction with a hydrophilic zwitterion ligand in a two-layer solvent containing an organic layer and an aqueous layer, in the presence of a phase transfer catalyst selected from salts of tetrabutyl ammonium, trioctylmethyl ammonium, benzyldimethyloctadecyl ammonium, and/or benzyltributyl ammonium. The first solution containing a desiccant is prepared at 150 to 190°C, and the second solution containing an iron complex with said fatty acid is prepared at 0 to 120°C. At least one of said solutions contains a surface-active agent from the group consisting of C_10-22 fatty alcohols, C_10-22 fatty acids, and C_10-22 fatty amines. The first solution is sustained at 150 to 190°C, and the second solution is added thereto by drops, resulting in a mixed solution, the components whereof interact at 150 to 190°C, resulting in the production of said iron oxide nanoparticles.

EFFECT: invention allows for an increase in the output of the target product, reduction in the agglomeration of particles, reduction in the number of reagents and the duration of the process.

16 cl, 1 dwg, 16 tbl, 7 ex