NANOPARTICLE CONTAINING ITS CONTRAST FOR MAGNETIC RESONANCE IMAGING AND A ZWITTER-ION LIGAND COMPOUND Russian patent published in 2023 - IPC C07C211/63 C07C211/64 C07C309/13 C07D207/06 C07D211/34 C07D211/62 C07D217/10 C07F9/38 A61K49/06 B82Y15/00 

FIELD: organic chemistry and diagnostic imaging.

SUBSTANCE: nanoparticle having a contrast ability, containing the following: at least one zwitterionic ligand represented by formula (I); and a metal-based particle containing iron oxide, and at least one zwitterionic ligand forms a coordination bond with the metal-based particle, where R¹ represents a group represented by either formula (a) or formula (b), and R² represents either H or halogen, X¹ represents either a bond or methylene, X¹ represents optionally ethylene when R¹ represents a group represented by formula (a), X² represents C_1-5-alkylene, or X² optionally represents a bond when R¹ represents a group represented by formula (b), R^a and R^b represent methyl, and Y^- represents either SO₃^- or CO₂^-, R³ and R⁴ are the same or they are different from each other and represent H, C_1-3 alkyl, or halogen, n is 1, and i) when R¹ is the group represented by formula (a) and X¹ is methylene, R² optionally forms ethylene together with R^a or R^b, ii) when R¹ represents a group represented by formula (a) and X¹ represents ethylene, R² optionally forms methylene together with R^a or R^b is proposed. The invention also relates to an MRI contrast agent containing the said nanoparticle, the use of a zwitterionic ligand compound of formula (I), and a compound of formula (I).

EFFECT: group of inventions provides an effective contrast agent for MRI, which exhibits stable behavior in a living organism, has an excellent positive contrast ability (i.e., a high r1/r2 ratio), exhibits low toxicity to a living organism, and has good storage stability.

18 cl, 22 tbl, 7 dwg