METHOD OF PRODUCING ADAMANTYL-CONTAINING ISOTHIOCYANATES Russian patent published in 2016 - IPC C07C331/18 C07C331/26 

FIELD: chemistry.

SUBSTANCE: invention relates to chemistry of adamantane derivatives, specifically to a method of producing adamantyl-containing isothiocyanates, which are intermediate products for synthesis of biologically active substances. Proposed method of producing adamantyl-containing isothiocyanates involves reaction of adamantane derivative with an isothiocyanate derivative while boiling in a solvent medium followed by extraction and recrystallisation of reaction product from alcohol. Method is characterised by that adamantane derivative used is adamantyl-containing amine, selected from a series of 1-aminoadamantane, 1-(adamantan-1-yl)-ethane-1-amine or 1-amino-3,5-dimethyladamantane, and isothiocyanate derivative is phenylisothiocyanate. Reaction is carried out in a toluene medium for 3 hours in molar ratio adamantyl-containing amine : phenylisothiocyanate : toluene = 1.2:1:25. Product is separated by distilling solvent.

EFFECT: method enables to obtain desired isothiocyanates with high output using a simpler method.

1 cl, 3 ex